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KingriderHossein/README.md

Hossein Shahsavari

Bioinformatician | Research + Engineering

Bridging Biology and Engineering through Bioinformatics.

I am a bioinformatician with an undergraduate background in biology and graduate studies in engineering. I work at the intersection of biological questions, computational methods, and reliable scientific software.

My interests include computational systems biology, RNA-seq, genome-scale metabolic modeling, and multi-omics integration. I value transparent methods, reproducible analysis, and careful interpretation of evidence.

Research interests

  • Systems biology: constraint-based modeling, metabolic networks, and context-specific models
  • Cancer bioinformatics: transcriptomic analysis and cancer metabolism
  • Multi-omics integration: connecting molecular measurements to mechanistic models
  • Reproducible research: traceable data, validated workflows, and clearly documented limitations

Selected projects

Project Focus
RNASeqAnalysisWithSalmon Reanalysis of prostate cancer RNA-seq using Salmon, tximport, and DESeq2; includes checks and comparison with published findings. Final scientific review is ongoing.
AuxoYeast Reproducibility Audit Notebook-based reproducibility investigation of yeast genome-scale metabolic model curation and auxotrophy predictions.
Bioinformatics Intelligence Radar Evidence-oriented monitoring with structured records, validation, and testable Python components.
Biology Resource Registry Structured, subject-based biology learning resources and documented learning pathways.
RNA-Seq R Course Educational material for learning RNA-seq analysis using R.

Tools and methods

Programming: Python · R · Bash
Bioinformatics: Salmon · tximport · DESeq2 · COBRApy · SBML
Research computing: Linux · Jupyter · Git · GitHub Actions

Current research direction

I am exploring the integration of multi-omics data with context-specific human genome-scale metabolic models, particularly for studying cancer metabolism.

I aim to combine biological interpretation with maintainable, testable computational workflows while documenting scientific uncertainty and limitations.

Collaboration

I am interested in computational biology, systems biology, and open scientific software. For project-specific discussions, please open an issue in the relevant repository.

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