trypsin_benzamidine_hmm tpt analysis fails

[marscher]

CellExecutionError: An error occurred while executing the following cell:
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tpt = msm.tpt(bhmm, [i_meta_unbound], [i_meta_bound])
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ValueError: Sets A and B have to be disjoint

[marscher]

We can not find the unbound and bound state reliably with the provided data?