Issues

• Add a batch/POST endpoint for /homology/id and /homology/symbol

  Ensembl/ensembl-rest#714 · Filter by author rbutleriii opened on Sep 9, 2026

• REST API returning 503 / Read Timeout (rest.ensembl.org unreachable since ~07:00 UTC July 29)

  Ensembl/ensembl-rest#713 · Filter by author sgao-academics opened on Jul 29, 2026
  1

• VEP API returns invalid JSON when using allele string "NAN"

  Ensembl/ensembl-rest#710 · Filter by author bprize15 opened on Mar 25, 2026
  1

• Please add an option to VEP (GRCh37 REST) to be able to annotate HGVSc for variants upstream or downstream of the transcript

  Ensembl/ensembl-rest#704 · Filter by author Karthik-Tempus opened on Feb 13, 2026
  2

• VEP (GRCh37 REST) is not annotating HGVSc for variants that span the region outside and within a transcript

  Ensembl/ensembl-rest#703 · Filter by author Karthik-Tempus opened on Feb 13, 2026
  1

• VEP (GRCh37 REST) did not annotate some of the overlapping transcripts/genes for a variant

  Ensembl/ensembl-rest#702 · Filter by author Karthik-Tempus opened on Feb 12, 2026
  1

• HGVSg and HGVSc notation generated by the REST API response are incorrect for some variants

  Bug

  Ensembl/ensembl-rest#694 · Filter by author Karthik-Tempus opened on Aug 13, 2025
  1

• Inconsistent behaviour of VEP POST endpoint

  Ensembl/ensembl-rest#675 · Filter by author DSuveges opened on Jan 16, 2025
  

• Add shift_hgvs flag as an option to REST API (vep/:species/hgvs/:hgvs_notation)

  enhancement
  Ensembl/ensembl-rest#663 · Filter by author Karthik-Tempus opened on Sep 17, 2024
  3